Structurally, these members are all characterized by a highly conserved C-terminal domain and a variable N-terminal domain. The LOX family, a type of secreted copper-dependent amine oxidases, is comprised of five homologous members: LOX and lysyl oxidase-like proteins 1–4 (LOXL1, LOXL2, LOX元 and LOXL4) ( Molnar et al., 2003). The lysyl oxidase (LOX) family, which are well known as ECM-modifying proteins, they participate in the crosslinking of collagens and elastin in the ECM, promoting its maturation ( Yamauchi et al., 2018b Chitty et al., 2019). The remodeling of the ECM in cancer plays an important role in controlling the progression of disease and influences cell growth, motility and survival ( Yamauchi et al., 2018a). The extracellular matrix (ECM) is a complex network of secreted molecules, the function of which is to program cell behavior including supporting cell adhesion, survival and migration.
As a result, it is of great importance to further identify novel diagnostic and prognostic biomarkers in terms of the biological complexity, poor prognosis and high reoccurrence of GC ( Kang et al., 2018).
Despite major advances in understanding the epidemiology, pathology, and molecular mechanisms of GC and in implementing emerging therapeutic options such as targeted and immune-based therapies, not all patients respond to existing molecularly targeted agents developed for certain acknowledged biomarkers ( Chau, 2017). However, due to its advanced-stage diagnosis, excess mortality from this cancer is high, making GC the third most common cause of cancer related death with 784,000 deaths globally ( Bray et al., 2018).
Results: The mRNA expression levels of LOX, LOXL1 and LOXL2 were significantly higher in GC, the expression level of LOX元 was contrary in different databases, while the expression level of LOXL4 made no difference the expression levels of LOX, LOXL1 and LOX元 were higher in stages 2–4 than that of normal tissues and stage 1, while the mRNA level of LOXL2 in stage 1–4 was higher than normal tissues patients with high expression of LOX and LOXL 2-4 had poor OS the genes correlated with LOX and LOXL2 were enriched in extracellular matrix organization, vasculature development and skeletal system development.Ĭonclusion: Our results indicated that the LOX family, especially LOX and LOXL2, might play an important role in GC oncogenesis, and they may become biomarkers for predicting tumor prognosis and potential targets for tumor therapy.Įven though declines in (GC)incidence and mortality rates have been observed consistently across world regions, GC remains the fifth most commonly diagnosed malignancy worldwide, with over 1 million estimated new cases in 2018 ( Bray et al., 2018). Methods: ONCOMINE, GEPIA, UALCAN, Kaplan–Meier Plotter, LOGpc, cBioPortal, GeneMANIA and Metascape databases were utilized in this study to analyze the expression, prognostic values, mutations and functional networks of LOX family in GC. However, the diverse expression patterns and prognostic values of LOX family in GC have yet to be systematically analyzed. The lysyl oxidase (LOX) family, a type of secreted copper-dependent amine oxidases, is comprised of LOX and four LOX-like (LOXL) 1–4 isoforms and has been reported to be dysregulated in a number of different type cancers. 3Radiology Department, The Second Hospital of Tianjin Medical University, Tianjin, Chinaīackground: Gastric cancer (GC) remains the fifth most commonly diagnosed malignancy worldwide, with a poor prognosis.2Department of Respiratory, The Second Hospital of Tianjin Medical University, Tianjin, China.1Department of Gastrointestinal Surgery, The Second Hospital of Tianjin Medical University, Tianjin, China.Li Wang 1 †, Shan Cao 2 †, Rujun Zhai 1, Yang Zhao 3 and Guodong Song 1*
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